8 Reasons Why Men Over 40 Are Switching To 10,000 FU Nattokinase
If you’ve taken nattokinase and felt nothing, reason #2 is probably why

Go get your nattokinase bottle out of the cabinet. Turn it around.
If the label only tells you milligrams, keep reading. If it says 2,000 FU, definitely keep reading.
Here are the 8 reasons men over 40 are switching.
Reason #1: Milligrams are not strength
Nattokinase is an enzyme. Its strength is measured in FU (fibrinolytic units), basically how much fibrin it can help break down.
Milligrams only tell you the weight of the powder. Two bottles can both say “100 mg” and do very different amounts of work.
A former vitamin-store manager put it bluntly to us: “Our best seller said 100 mg on the front. It worked out to about 2,000 FU. Nobody on my team could explain what that meant.”
Reason #2: 2,000 FU was tested for 3 years and found nothing measurable
This is the one that makes men angry.
A 3-year trial published in 2021 gave adults 2,000 FU of nattokinase every day. The result was no measurable difference compared with placebo.
That’s a common shelf dose. Many men did everything right (listened to their doctor, bought the bottle, took it for months) and got the dose that didn’t measure up.
We call it the shelf dose: the amount that fits a price point, not a study.
Reason #3: The 10,000 FU range is where the research points
A 12-month study of 1,062 people used a daily dose in the 10,000 FU range. A lower dose in the same study, 3,600 FU, didn’t show the same result.
So the switch isn’t from “no nattokinase” to “nattokinase.” It’s from the shelf dose to the studied range.
It’s like a space heater on the lowest setting in January. It’s plugged in, the light’s on, you’re paying for it, and the room stays cold. Then you decide space heaters don’t work.
Reason #4: After 40, your body clears less fibrin

Fibrin is the sticky protein mesh your blood uses to seal a cut. Younger bodies clear the leftovers efficiently. After 40, they clear less of it, and blood runs a little thicker.
Nattokinase helps your body break down fibrin.† That’s the whole reason the dose matters.
Reason #5: The smallest arteries warn first
A 2003 study in European Urology examined 300 men with heart disease. Among those who also had erection problems, about 2 out of 3 had them first, about three years before chest symptoms on average.
The reason: the arteries behind a man’s mornings are some of the narrowest on the path. When blood runs thicker, they notice first.
That’s why so many men who switch are really thinking about their heart.
Reason #6: CoQ10 belongs in the same capsule
CoQ10 is the fuel your heart muscle runs on.† Your body makes less of it with every birthday, and statins can lower it further.
Men who are switching want both in one place: the enzyme for the path and the fuel for the pump. (Keep your statin. Just cover the CoQ10.)
Reason #7: One capsule, not a cabinet

Men stop taking routines that need 4 pills. The formula men are switching to, Novarate, puts 8 actives in 1 capsule:
- 10,000 FU nattokinase†;
- CoQ10†;
- pine bark, aged garlic, grape seed, for healthy blood flow and circulation†;
- turmeric, bromelain and dandelion.
One capsule with breakfast. It supports healthy blood flow and circulation, all the way to the heart.†
Reason #8: You keep the bottles even if it doesn’t work for you
Novarate has a 90-day guarantee: if it does nothing for you, you get a refund and you keep the bottles.
After paying for a shelf dose for months, that’s the part men tell us made the switch easy.
*Individual experiences vary.
What men notice, and when
- Week 1: usually nothing. That’s normal.
- Weeks 2–4: warmer hands and feet†.
- Weeks 3–6: lighter legs†.
- Weeks 4–8: steadier energy†, and for many men, mornings they notice.*
